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Year : 2016  |  Volume : 3  |  Issue : 1  |  Page : 46-48

Inheritance pattern of hypopigmented macules associated with familial Darier's disease

1 Department of Dermatology, Government Medical College, Amritsar, Punjab, India
2 Department of Pathology, Government Medical College, Amritsar, Punjab, India

Correspondence Address:
Dr. Nidhi Sharma
207, Basant Avenue, Amritsar, Punjab
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2349-5847.184268

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Hypopigmented macules or guttate leukoderma is a rarely reported association of Darier's disease largely reported in dark colored individuals. So far, the pathogenesis of hypopigmented macules has been only partially explained by varying hypotheses such as post inflammatory phenomenon, an early or subclinical variant of disease, and genetic mosaicism. We describe a case of a 32-year-old male of Indian origin suffering from multigenerational Darier's disease associated with hypopigmented macules over the trunk. Classical warty papules and plaques were present in three generations thus highlighting autosomal dominant inheritance of the disease. The hypopigmented macules were found only in the proband thereby signifying its nonfamilial manner of inheritance.

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