| CASE REPORT |
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| Year : 2017 | Volume
: 4
| Issue : 2 | Page : 115-117 |
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Squamous cell carcinoma on vitiligo patch: A rare association
Anita Vijay, Suresh K Jain, Ramesh Kumar
Department of Dermatology, Venereology and Leprology, Government Medical College, Kota, Rajasthan, India
Correspondence Address:
Suresh K Jain
Department of Dermatology, Venereology and Leprology, Government Medical College, Kota, Rajasthan 324 005
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/2349-5847.219682
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Vitiligo is an immune-mediated disease characterized by idiopathic destruction of melanocyte. The loss of pigment melanin predisposes vitiligo patients to photosensitivity and early photodamage. Despite this, the incidence of squamous cell carcinoma (SCC) is not found to be increased in vitiligo. SCC is a common malignancy of keratinocytes that arises in sites of exposure to excessive ultraviolet radiation. Various theories have been proposed for lower incidence of SCC in vitiligo. These include decrease in cytokines, such as transforming growth factor-β and IL-10, along with increase in IL-1, TNF-α, p53, superoxide dismutase, and glutathione peroxidase. We hereby report a rare case of SCC arising in a patient with longstanding vitiligo of photoprotected skin with no history of phototherapy.
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