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Year : 2017  |  Volume : 4  |  Issue : 2  |  Page : 78-84

Systemic therapy for melasma: Exploring newer options − A comprehensive review

1 Department of Dermatology, College of Medicine and Sagore Dutta Hospital, Kolkata, West Bengal, India
2 Department of Dermatology, Maulana Azad Medical College, New Delhi, India

Correspondence Address:
Indrashis Podder
Department of Dermatology, College of Medicine and Sagore Dutta Hospital, Kolkata, West Bengal
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2349-5847.219672

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Melasma is a chronic, hyperpigmentary disorder affecting the face, more commonly the females and has a significant psychological and social impact. Currently available treatment options such as prevention of ultraviolet radiation, topical lightening agents, chemical peels and light-based or laser therapies are useful in the short run but fail to produce a sustained improvement and complete clearance. The condition frequently recurs after successful treatment. Thus, the search is on for efficacious systemic agents which would help in maintaining remission and prevent relapses. Many of the oral agents provide improved results when used as adjuncts, with minimal side effects and may help to achieve quicker, better and long-lasting results. This article aims to review the efficacy, safety and tolerability of different systemic anti-melasma agents.

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