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Year : 2021  |  Volume : 8  |  Issue : 2  |  Page : 73-75

The role of the mast cell in pigmentation disorders

1 Department of Dermato-Venereology & Wound Healing Centre, Bispebjerg Hospital, Copenhagen, Denmark
2 Department of Dermato-Venereology & Wound Healing Centre, Bispebjerg Hospital; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

Correspondence Address:
Valdemar Wendelboe Nielsen
Department of Dermato-Venereology and Wound Healing Centre, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 Copenhagen NV
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/pigmentinternational.pigmentinternational_

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The mast cell is a critical mediator of the inflammatory response by secreting histamine. While histamine is currently not regarded as a melanogen, recent studies have shown histamine release to induce melanogenesis, melanocyte proliferation and migration. Herein, we discuss the current evidence of the complex relationship between the mast cell and melanocyte, and its impact in pigmentation disorders.

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