Home About us Editorial board Ahead of print Current issue Archives Instructions Submit article Search Subscribe Contacts Login
  • Users Online: 598
  • Home
  • Print this page
  • Email this page
Year : 2021  |  Volume : 8  |  Issue : 2  |  Page : 86-94

Study of contact sensitivity to cosmetic allergens in melasma

1 Department of Dermatology, Maulana Azad Medical College & Associated Lok Nayak Hospital, Bahadur Shah Zafar Marg, New Delhi, India
2 Department of Dermatology, Lady Hardinge Medical College & Associated SSK and KSCH Hospitals, New Delhi, India

Correspondence Address:
Dr. Rashmi Sarkar
Department of Dermatology, Lady Hardinge Medical College and Associated SSK and KSC Hospitals, New Delhi, 110002
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/pigmentinternational.pigmentinternational_

Rights and Permissions

Introduction: Melasma is a relatively common hypermelanotic disorder characterized by symmetrical light to gray-brown macules and patches involving photoexposed areas. Multiple factors have been implicated in the etiopathogenesis, including genetic factors, UV radiation, pregnancy, oral contraceptive pills (OCPs), thyroid dysfunction, and cosmetics. However, the role of cosmetics has not been well studied in melasma patients. The present study was designed to study the contact sensitivity to cosmetic allergens in patients with melasma. Material and Methods: Thirty patients with and thirty without melasma who visited Dermatology OPD between October 2015 and March 2017 were recruited according to selection criteria and were sequentially patch and photopatched with Indian cosmetic and fragrance series. Results: The mean age of melasma patients was 32.10 ± 6.62 years with female to male ratio of 1.72:1. Sixteen (53%) patients were found to show positive reactions on patch and photopatch testing with Indian cosmetic and fragrance series. Among 32 allergens tested, 15 allergens were found eliciting positive reaction. Thiomersol was the most common contact sensitizer eliciting positive reaction in six (38%) patients, followed by cetrimide, hexamine, and sorbitan each in three patients (19%). In the control group, only one (3.3%) subject showed positive contact allergy pattern. The results were significant (P < 0.001). Conclusion: A possible consideration of the pigmented cosmetic dermatitis and cosmetic contact sensitivity is recommended in the etiologic factors of melasma especially, in nonpregnancy/lactation induced melasma or when it is not associated with hormone therapy. Contact sensitizers might also have a role in melasma that is recalcitrant to all standard therapies.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded110    
    Comments [Add]    

Recommend this journal